Funding Acknowledgement: The study is funded by National Institute for Health and Care Research (NIHR) HTA programme (NIHR133464). The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health and Social Care.
Bristol Trials Centre Acknowledgement: This trial was designed and delivered in collaboration with the Bristol Trials Centre, a UKCRC registered clinical trials unit, which is in receipt of National Institute for Health & Care Research CTU support funding.
Sponsor Acknowledgement: This trial is sponsored by the University of Bristol.
CPMS ID: 54714
IRAS: 318832
REC: 22/NW/0387
ISRCTN: ISRCTN52892540
